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Updated: Aug 15, 2026

Imaging of HIV-1 Envelope-induced Virological Synapse and Signaling on Synthetic Lipid Bilayers
Published on: March 8, 2012
Mechanisms of opsonized HIV entry in normal B lymphocytes
C Legendre1, G Gras, R Krzysiek
1Service de Neurovirologie, CE-FAR, DSV/DRM/SNV, IPSC, Fontenay aux Roses, France.
Abstract:
Using our in vitro model of normal B cell infection that functions with low doses of HIV but requires virus opsonization by seropositive patient serum, and complement, we analyzed what receptors allowed virus entry. Here, we show that HIV infection of B cells occurs through 2 major receptors: the CD4 antigen and the CR1/CR2 complex. These 2 pathways work independently since a complete inhibition of virus entry requires both CD4 and CD21/CD35 blockade on CD4dim tonsillar B cells whereas only the latter is critical on CD4-negative B cells.
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