Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lomotil poisoning in children: two case reports

S M Block, R Dansky, M D Davis

    South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
    |April 16, 1977
    PubMed
    Summary

    Lomotil, a common antidiarrhoeal, can cause severe central nervous system depression and atropinism. Prompt treatment with gastric emptying, antagonists, and charcoal is crucial for managing Lomotil poisoning.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Preliminary method for profiling volatile organic compounds in breath that correlate with pulmonary function and other clinical traits of subjects diagnosed with cystic fibrosis: a pilot study.

    Journal of breath research·2022
    Same author

    Autoimmune myelofibrosis with pancytopenia as a presenting manifestation of systemic lupus erythematosus responsive to mycophenolate mofetil.

    Lupus·2015
    Same author

    Antibodies to influenza A virus (H1 and H3) in companion animals in Iowa, USA.

    The Veterinary record·2011
    Same author

    Optical trapping of metallic Rayleigh particles.

    Optics letters·2009
    Same author

    Neurophysiologic and vascular studies in erythromelalgia: a retrospective analysis.

    Journal of clinical neuromuscular disease·2008
    Same author

    Sustained moderate visual loss as a predictive end point for visual loss in non-proliferative diabetic retinopathy.

    Eye (London, England)·2008

    Area of Science:

    • Pharmacology
    • Toxicology
    • Emergency Medicine

    Background:

    • Lomotil (diphenoxylate/atropine) is a widely prescribed antidiarrhoeal medication.
    • Overdose can lead to serious adverse effects, necessitating prompt medical intervention.

    Observation:

    • Two cases of Lomotil poisoning are presented, including one fatality.
    • Clinical manifestations included significant central nervous system depression and signs of atropinism.

    Findings:

    • Poisoning symptoms correlate with the central nervous system depressant and anticholinergic effects of Lomotil's components.
    • Effective management involves a multi-modal approach to mitigate toxicity.

    Implications:

    • Highlights the critical need for awareness of Lomotil's overdose potential in clinical practice.
    • Emphasizes the importance of timely and appropriate interventions for Lomotil-induced poisoning.
    • Underscores the role of supportive care and specific antidotes in managing overdose cases.

    Related Experiment Videos