Related Experiment Video
Updated: Sep 7, 2026

Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function
Published on: June 11, 2017
Killing of arterial smooth muscle cells by chylomicron remnants
Abstract:
Chylomicron remnants were found to be cytotoxic to cultured arterial smooth muscle cells. Cell death was estimated by two methods: colourimetric assay using a tetrazolium salt ahd trypan blue staining. Both methods showed considerable cell death. Twenty-five micrograms of cholesterol/ml of chylomicron remnants appeared not to injure smooth muscle cells; however, greater concentrations (= and >50 microg cholesterol/ml) caused considerable damage. Our observations may offer a possible cause of cell death in atherosclerotic plaques.
More Related Videos
09:06Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
Published on: February 20, 2019
06:14The Isolation of Flowing Mesenteric Lymph in Mice to Quantify In Vivo Kinetics of Dietary Lipid Absorption and Chylomicron Secretion
Published on: November 30, 2022
Related Concept Videos
Inflammation
Vascular Spasm
Lipid Absorption
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
Coronary Artery Disease II: Pathophysiology
Atherosclerosis I: Introduction
Peripheral Artery Disease I: Introduction