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Pulp response to a novel adhesive calcium hydroxide based cement
A Watts1, R C Paterson, B D Cohen
1Glasgow Dental Hospital and School, UK.
The European Journal of Prosthodontics and Restorative Dentistry
|September 1, 1994
Summary
An experimental adhesive calcium hydroxide cement demonstrated comparable pulp healing to Dycal and standard calcium hydroxide, forming dentine bridges in most teeth. Further research is needed to understand remote inflammatory responses and bacterial presence.
Area of Science:
- Dentistry
- Biomaterials Science
- Regenerative Medicine
Background:
- Calcium hydroxide (Ca(OH)2) is a widely used dental material for pulp capping.
- Different formulations of calcium hydroxide exist, potentially influencing pulp response and dentin bridge formation.
- Understanding the efficacy of novel adhesive calcium hydroxide formulations is crucial for clinical application.
Purpose of the Study:
- To compare the pulp responses to an experimental adhesive calcium hydroxide cement against two established calcium hydroxide formulations.
- To evaluate the dentin bridge formation and inflammatory responses induced by these materials.
- To assess the potential for bacterial contamination and associated inflammatory reactions.
Main Methods:
- Exposed rat molar pulps were capped with three different calcium hydroxide formulations: an experimental adhesive cement, Dycal, and a mixture of "Analar" calcium hydroxide with sterile distilled water.
- Pulp responses, including dentin bridge formation and inflammatory cell infiltration, were assessed after 28 days.
- Histological examination was performed to detect the presence of bacteria and inflammatory infiltrates.
Main Results:
- Dentin bridges were observed in 77% of teeth treated with the experimental adhesive calcium hydroxide, 64% with Dycal, and 62% with "Analar" calcium hydroxide.
- Inflammatory infiltrates were noted in teeth distant from the capped sites, with bacterial detection in these areas.
- The experimental adhesive calcium hydroxide cement elicited pulp responses similar to the other tested calcium hydroxide formulations.
Conclusions:
- The experimental adhesive calcium hydroxide cement shows comparable efficacy to Dycal and standard calcium hydroxide in promoting dentin bridge formation.
- The presence of bacteria and remote inflammatory infiltrates suggests potential challenges or limitations that warrant further investigation.
- Further studies are needed to elucidate the mechanisms behind remote inflammation and to optimize adhesive calcium hydroxide formulations for enhanced clinical outcomes.