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JMH variants: serologic, clinical, and biochemical analyses in two cases
1Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Transfusion
|November 1, 1995
Summary
Individuals with the JMH-variant antigen can produce clinically significant alloanti-JMH antibodies. This variant antigen, found on red blood cells, follows an autosomal recessive inheritance pattern.
Area of Science:
- Immunology
- Genetics
- Hematology
Background:
- The JMH antigen (CDw108) is a high-frequency red blood cell surface protein.
- Autoimmune anti-JMH antibodies are typically benign, but the clinical significance of alloanti-JMH is less understood.
Observation:
- Two patients with a JMH-variant antigen phenotype were identified.
- These patients produced alloanti-JMH antibodies.
Findings:
- JMH-variant red cells express a normal molecular weight JMH protein.
- The JMH-variant phenotype is inherited in an autosomal recessive pattern.
- Reduced in vivo red blood cell survival was observed in one patient.
Implications:
- Individuals with the JMH-variant phenotype can develop clinically significant alloanti-JMH antibodies.
- This finding is crucial for transfusion medicine and understanding red blood cell antigen variability.