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Related Experiment Videos

Institutional variation in hemotherapy for solid organ transplantation

C F Danielson1, R S Filo, J A O'Donnell

  • 1Department of Pathology and Laboratory Medicine, Indiana University Medical Center, USA.

Transfusion
|March 1, 1996
PubMed
Summary

Solid organ transplant recipients, especially liver transplant patients, need significant blood products. Transfusion services modify blood components, like cytomegalovirus-safe options, to enhance safety for immunosuppressed patients.

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Area of Science:

  • Transplantation Medicine
  • Hematology
  • Blood Banking

Background:

  • Solid organ allograft recipients often require substantial blood component transfusions.
  • Modifications to blood components for immunosuppressed transplant patients increase blood bank workload.

Purpose of the Study:

  • To survey transfusion practices for solid organ transplant recipients in the United States and Canada.
  • To identify variations in hemotherapy support among different transplant types.

Main Methods:

  • A survey was distributed to institutions in the US and Canada providing hemotherapy for transplant recipients.
  • Data from 25 responding institutions were analyzed.

Main Results:

  • Liver transplant recipients had the highest intraoperative red cell requirements (mean 17.3 units).

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  • Most institutions provided cytomegalovirus-safe or white cell-reduced components to pediatric liver, and adult/pediatric heart, lung, and heart-lung allograft recipients.
  • Irradiated components and pretransplantation transfusions for immunomodulation were used less frequently.

    • Conclusions:

    • Transfusion practices vary, but cytomegalovirus-safe components are common for heart, lung, and pediatric transplant recipients.
    • Gamma-irradiated components are not routinely used in solid organ transplantation.
    • Liver allograft recipients necessitate the most extensive hemotherapeutic support.