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Hepatitis C virus infection in pregnancy
A Floreani1, D Paternoster, F Zappala
1Department of Gastroenterology, Institute of Internal Medicine, University of Padova, Italy.
British Journal of Obstetrics and Gynaecology
|April 1, 1996
Summary
Hepatitis C virus (HCV) infection in pregnant women does not worsen liver disease or increase obstetric risks. Most mothers, even if asymptomatic, carry HCV RNA, but pregnancy outcomes remain favorable.
Area of Science:
- Hepatology
- Virology
- Obstetrics & Gynecology
Background:
- Hepatitis C virus (HCV) is a significant global health concern.
- Understanding the impact of HCV on pregnancy is crucial for maternal and infant health.
- Clinical management of HCV in pregnant populations requires careful evaluation.
Purpose of the Study:
- To assess the clinical manifestations of HCV liver disease in pregnant women.
- To evaluate the course of HCV infection during pregnancy and postpartum.
- To determine the pregnancy outcomes in mothers with anti-HCV antibodies.
Main Methods:
- A cohort of 1700 pregnant women underwent serological screening for viral infections, including HCV.
- Clinical and biochemical assessments were performed to identify liver disease and risk factors.
- Follow-up included assessments during pregnancy and six months postpartum.
Main Results:
- 1.7% (29/1700) of pregnant women tested positive for anti-HCV antibodies.
- HCV-RNA was detected in 64.2% of anti-HCV positive women.
- Pregnancy outcomes were favorable for all women, with no increased risk of obstetric complications attributed to HCV.
Conclusions:
- A significant number of anti-HCV positive pregnant women, including asymptomatic cases, harbor circulating HCV-RNA.
- Pregnancy does not appear to exacerbate liver disease in mothers with HCV.
- HCV infection does not pose an increased risk for obstetric complications.