Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ruminant pestiviruses

P F Nettleton1, G Entrican

  • 1Moredun Research Institute, Edinburgh, Scotland.

The British Veterinary Journal
|November 1, 1995
PubMed
Summary
This summary is machine-generated.

Ruminant pestiviruses like BVDV and BDV cause persistent infections in fetuses. Current diagnostics and vaccines are limited, highlighting the need for better control strategies against these important animal pathogens.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Herpesvirus infection in Cervidae.

Revue scientifique et technique (International Office of Epizootics)·2020
Same author

Late production of CXCL8 in ruminant oro-nasal turbinate cells in response to Chlamydia abortus infection.

Veterinary immunology and immunopathology·2015
Same author

Prevalence of antibodies to bovine viral diarrhoea virus in bulk tank milk and associated risk factors in Scottish dairy herds.

The Veterinary record·2012
Same author

Lymphoid and myeloid cell populations in the non-pregnant human Fallopian tube and in ectopic pregnancy.

Journal of reproductive immunology·2011
Same author

Ectopic lymphoid tissue formation in the lungs of mice infected with Chlamydia pneumoniae is associated with epithelial macrophage inflammatory protein-2/CXCL2 expression.

Clinical and experimental immunology·2010
Same author

Production and characterization of two monoclonal antibodies to bovine tumour necrosis factor alpha (TNF-alpha) and their cross-reactivity with ovine TNF-alpha.

Veterinary immunology and immunopathology·2010

Area of Science:

  • Veterinary Virology
  • Infectious Diseases
  • Ruminant Pathogens

Background:

  • Bovine virus diarrhoea virus (BVDV) and border disease virus (BDV) are significant ruminant pathogens.
  • Pestiviruses exhibit two antigenic groups, primarily affecting cattle and sheep.
  • Non-cytopathic (NCP) pestiviruses establish persistent fetal infections (PI), while cytopathic (CP) forms cause mucosal disease.

Purpose of the Study:

  • Clarify serological relationships among ruminant pestiviruses.
  • Investigate the molecular origins of CP pestiviruses from NCP strains.
  • Address the lack of effective vaccines and reliable diagnostic tools for pestivirus control.

Main Methods:

  • Review of molecular evidence for CP virus emergence.
  • Analysis of diagnostic techniques for PI and convalescent animals.

Related Experiment Videos

  • Assessment of vaccine efficacy in preventing fetal pestivirus infection.

    • Main Results:

    • CP pestiviruses likely arise from NCP counterparts via recombination.
    • Monoclonal antibody-based ELISAs offer specific, rapid, and reliable diagnostics for PI animals.
    • No commercial vaccine currently prevents fetal pestivirus infection in dams.

    Conclusions:

    • Effective control of ruminant pestiviruses relies on accurate diagnostics due to limited vaccine options.
    • Advancements in molecular techniques are improving pestivirus detection and identification.
    • Further research is needed to understand CP virus pathogenesis and develop improved control strategies.