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Detection of methylating activity due to nitrosamide in some nitrosated Nigerian foodstuffs

S E Atawodi1, P Mende, R Preussmann

  • 1Division of Toxicology and Cancer Risk Factors, German Cancer Research Centre, Heidelberg, Germany.

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
|February 1, 1996
PubMed

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Secondary amines react with nitrous acid to form N-nitrosamines, as depicted in Figure 1. Nitrous acid, a weak and unstable acid, is formed in situ from an aqueous solution of sodium nitrite and strong acids, such as hydrochloric acid or sulfuric acid, in cold conditions. In the presence of an acid, the nitrous acid gets protonated. The subsequent loss of water results in the formation of the electrophile known as nitrosonium ion.