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A case of autoimmune hemolytic anemia induced by IFN-beta therapy for type-C chronic hepatitis
Y Kazuta1, N Watanabe, K Sagawa
1Department of Internal Medicine, Hanawa Kohsei Hospital, Fukushima, Japan.
Fukushima Journal of Medical Science
|June 1, 1995
Abstract:
A 51-year old woman who had type-C chronic hepatitis developed autoimmune hemolytic anemia after 4 weeks treatment with a total 48 million interferon-beta, 6 million 8 times. Indirect Coomb's test turned from negative to positive through IFN therapy and a complication of asymptomatic primary biliary cirrhosis was confirmed by histologic findings of the biopsied liver which was performed during IFN therapy and a presence of anti-mitochondrial antibody. After stopping IFN therapy and adding prednisolone anemia improved in getting negative indirect Coombs test but remaining positive direct Coombs test.