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CD36 and intercellular adhesion molecule 1 mediate adhesion of developing Plasmodium falciparum gametocytes
N J Rogers1, O Daramola, G A Targett
1Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, United Kingdom.
Infection and Immunity
|April 1, 1996
Abstract:
Plasmodium falciparum trophozoite-infected erythrocytes adhere to the amelanotic melanoma C32 cell line in vitro. Here we demonstrate for the first time that immature gametocyte-infected erythrocytes also adhere to C32 cells, albeit at lower levels than trophozoites. However, anti-CD36 and anti-intercellular adhesion molecule 1 antibodies inhibit asexual and gametocyte adhesion by comparable percentages, suggesting a common dependency for binding to these cellular receptors.