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Related Experiment Video

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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

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Selective screening for dyslipidemia in a Canadian population

B A Reeder¹, L Liu, L Horlick

¹Saskatchewan Heart and Stroke Foundation Epidemiology Unit, Department of Community Health and Epidemiology, Saskatoon, Canada.

Journal of Clinical Epidemiology

|February 1, 1996

Summary

Selective screening for dyslipidemia using a high waist-to-hip circumference ratio (WHR) is effective. This method identifies individuals with abnormal cholesterol levels, potentially improving population health management.

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Area of Science:

Cardiology
Public Health
Clinical Biochemistry

Background:

Dyslipidemia, characterized by abnormal plasma lipid levels, is a significant risk factor for cardiovascular disease.
Effective screening strategies are crucial for early detection and management of dyslipidemia in the adult population.

Purpose of the Study:

To evaluate clinical features that facilitate effective selective screening for dyslipidemia in adults.
To compare the efficacy of total cholesterol (TC) screening versus selective screening based on waist-to-hip circumference ratio (WHR).

Main Methods:

Analysis of data from the 1990 Saskatchewan Heart Health Survey, including plasma cholesterol and WHR measurements.
Dyslipidemia defined as a total cholesterol (TC) to high-density lipoprotein cholesterol (HDL) ratio of ≥ 5.
Calculation of sensitivity and specificity for different screening approaches.

Main Results:

Universal TC screening identified 79% of dyslipidemia cases but had lower specificity (67%).
Selective screening using high WHR required screening 44% of the population, identifying 71% of dyslipidemia cases with 66% specificity.
High WHR was a particularly strong predictor of dyslipidemia in younger adults.

Conclusions:

A high waist-to-hip circumference ratio (WHR) may serve as an effective tool for selective screening of dyslipidemia in the adult population.
Selective screening based on WHR offers a potential alternative to universal cholesterol testing, especially for optimizing resource allocation.