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Physiological red cell, 2,3-diphosphoglycerate increase by the sixth hour after birth
O C Barretto1, K Nonoyama, A D Deutsch
1Institute of Psychiatry LIM-23, University of São Paulo Medical School, Brazil.
Journal of Perinatal Medicine
|January 1, 1995
Summary
Newborns show a significant 30% increase in red blood cell 2,3-diphosphoglycerate (2,3-DPG) within six hours after birth. This rise in 2,3-DPG aids oxygen release to tissues, supporting infant adaptation.
Area of Science:
- Neonatal physiology
- Biochemistry
- Hematology
Background:
- High hemoglobin A1 levels at birth (20-30%) may necessitate mechanisms for efficient oxygen release.
- Increased blood pH and elevated red cell 2,3-diphosphoglycerate (2,3-DPG) are hypothesized to decrease hemoglobin affinity for oxygen, facilitating tissue oxygenation.
Purpose of the Study:
- To investigate the levels of 2,3-DPG in newborns post-birth.
- To explore the enzymes involved in regulating 2,3-DPG levels and their role in neonatal adaptation.
Main Methods:
- Assayed 2,3-DPG levels in cord blood from 22 newborns.
- Measured 2,3-DPG at 6, 24, and 72 hours post-birth.
- Assessed enzymes involved in 2,3-DPG regulation, including 2,3-DPG phosphatase activity.
Main Results:
- 2,3-DPG levels were 9,770 ± 1,026 nmol/g Hb in cord blood.
- A significant 30% increase in 2,3-DPG was observed by 6 hours post-birth (12,773 ± 1,726 nmol/g Hb).
- A decrease in 2,3-DPG phosphatase activity was detected, potentially reducing 2,3-DPG breakdown.
Conclusions:
- The study confirms the hypothesis of increased 2,3-DPG levels in newborns shortly after birth.
- The observed rise in 2,3-DPG, along with decreased phosphatase activity, supports enhanced oxygen release to neonatal tissues.
- These findings highlight crucial physiological adaptations for oxygen delivery in the neonatal period.