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Prenatal detection of limb defects after chorionic villus sampling
B C Sheu1, M K Shyu, L H Tseng
1Department of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei.
Prenatal Diagnosis
|November 1, 1995
Summary
Severe limb defects were diagnosed via prenatal ultrasound after chorionic villus sampling (CVS). Pathological findings confirmed the ultrasound diagnoses, highlighting the need for vigilance.
Area of Science:
- Medical Imaging
- Prenatal Diagnosis
- Fetal Abnormalities
Background:
- First-trimester chorionic villus sampling (CVS) is a common prenatal diagnostic procedure.
- Limb defects are serious congenital anomalies that can be detected prenatally.
- The potential association between CVS and limb defects has been a subject of ongoing research and debate.
Observation:
- Two cases of severe limb defects were diagnosed using prenatal sonography.
- These diagnoses occurred following first-trimester chorionic villus sampling.
- Elective termination was performed, allowing for pathological examination.
Findings:
- Pathological examination results closely correlated with the prenatal sonographic findings.
- This correlation supports the accuracy of ultrasound in diagnosing limb defects post-CVS.
- The study presents sonographic and pathological evidence in two specific cases.
Implications:
- While the link between CVS and limb defects is debated, these findings warrant attention.
- Routine and careful ultrasound examinations are recommended for pregnant individuals who have undergone CVS.
- Enhanced fetal anomaly screening may be crucial in pregnancies with a history of chorionic villus sampling.