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Studies on glucocorticoid hormone actions in the regulation of human amnion PGHS
1Department of Obstetrics and Gynaecology, Pediatrics and Physiology, University of Alberta, Edmonton, Canada.
Reproduction, Fertility, and Development
|January 1, 1995
Abstract:
The human amnion is an excellent model in which to study the regulation of the expression of prostaglandin endoperoxide H synthase-2 (PGHS-2) mRNA by glucocorticoids, as glucocorticoids can both stimulate and inhibit PGHS activity and can have their stimulatory effect reversed to an inhibitory one. Our studies suggest the presence of a glucocorticoid-induced inhibitory protein which affects the post-transcriptional activity of PGHS-2 mRNA. Glucocorticoid-induced expression of PGHS-2 mRNA may be dependent on protein phosphorylation.