Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transgenic insertional mutagenesis. Applications to inner-ear genetics

R A Friedman1

  • 1Division of Otolaryngology/Head and Neck Surgery, University of California, San Diego, USA.

Archives of Otolaryngology--Head & Neck Surgery
|March 1, 1996
PubMed
Summary

Sophisticated molecular biology techniques advance inner-ear genetics. Transgenic technology overcomes genome complexity to directly characterize inner-ear gene mutations and phenotypes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cell Type-Specific Decomposition of Gingival Tissue Transcriptomes.

Journal of dental research·2021
Same author

FoxO1-dependent induction of acute myeloid leukemia by osteoblasts in mice.

Leukemia·2015
Same author

Psychoanalysis as medicine, psychoanalysis as religion.

Journal of religion and health·2013
Same author

Lung adenocarcinoma invasion in TGFbetaRII-deficient cells is mediated by CCL5/RANTES.

Oncogene·2007
Same author

Can pediatric residents interpret electrocardiograms?

Pediatric cardiology·2005
Same author

Long-term follow-up of arrhythmias in pediatric orthotopic heart transplant recipients: incidence and correlation with rejection.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2003

Area of Science:

  • Genetics
  • Molecular Biology
  • Otolaryngology

Background:

  • Recent advances in molecular biology have significantly impacted inner-ear genetics research.
  • Characterizing inner-ear mutations is challenging due to mammalian genome complexity and limited genetic markers.

Purpose of the Study:

  • To highlight the role of transgenic technology in advancing inner-ear genetics.
  • To discuss how transgenic approaches facilitate the molecular characterization of inner-ear mutations.

Main Methods:

  • Utilizing insertional mutagenesis via transgenic technology.
  • Employing targeted gene inactivation through homologous recombination.

Main Results:

  • Transgenic technology offers a direct route to studying gene function in the inner ear.

Related Experiment Videos

  • This approach enables the detailed characterization of mutant phenotypes at the genetic level.

    • Conclusions:

    • Transgenic technology is a powerful tool for overcoming previous limitations in inner-ear genetics.
    • Direct gene characterization through transgenic methods accelerates the understanding of inner-ear development and disease.