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Related Experiment Videos

Cancer mortality at very old ages

D W Smith1

  • 1Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611-3008, USA.

Cancer
|April 1, 1996
PubMed
Summary
This summary is machine-generated.

Cancer mortality rates peak in individuals aged 80-100 and decline thereafter. Survivors nearing 100 are resistant to common causes of death, including cancer, possibly due to genetic factors.

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Area of Science:

  • Gerontology
  • Oncology
  • Epidemiology

Background:

  • Cancer mortality generally increases with age throughout most of the human lifespan.
  • Previous research has not detailed cancer mortality trends in individuals aged 85 and older.
  • This study analyzes cancer mortality in distinct age groups beyond 85 years.

Purpose of the Study:

  • To describe age-specific cancer mortality rates near the end of the human lifespan.
  • To investigate cancer mortality patterns in individuals aged 85 years and older.
  • To compare cancer mortality trends across different advanced age groups.

Main Methods:

  • Utilized United States vital statistics and Census data from 1990.
  • Calculated age-stratified mortality rates for all malignant neoplasms combined.

Related Experiment Videos

  • Analyzed mortality rates for specific cancer sites in 5-year age groups from 50 to over 100 years.

    • Main Results:

    • Mortality rates for most cancers and all malignant neoplasms combined peak between ages 80 and 100 years.
    • Rates decline in individuals older than 100 years.
    • The proportion of cancer deaths among all deaths decreases significantly with extreme age, from 40% (ages 50-69) to 4% (over 100).

    Conclusions:

    • Individuals surviving to advanced ages (approaching 100) exhibit resistance to common causes of mortality, including cancer.
    • This resistance may be linked to genetic factors influencing cancer pathogenesis.
    • Extreme longevity is associated with a reduced susceptibility to cancer as a cause of death.