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Related Experiment Videos

Localized cisplatin hyperpigmentation induced by pressure. A case report

Z Al-Lamki1, P Pearson, N Jaffe

  • 1Department of Child Health, Sultan Qaboos University, Sultanate of Oman.

Cancer
|April 15, 1996
PubMed
Summary

Chemotherapy can cause skin hyperpigmentation, particularly with cisplatin. This study found localized pressure exacerbated cisplatin-induced hyperpigmentation along the thorax in a patient receiving chemotherapy for osteosarcoma.

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Area of Science:

  • Oncology
  • Dermatology
  • Pharmacology

Background:

  • Chemotherapy, including alkylating agents and doxorubicin, can induce skin hyperpigmentation.
  • Intra-arterial cisplatin treatment has been associated with hyperpigmentation on extremities and surgical sites.
  • The exact mechanisms and contributing factors for chemotherapy-induced hyperpigmentation require further investigation.

Observation:

  • A patient with osteosarcoma developed hyperpigmentation along the thorax.
  • The hyperpigmentation occurred in areas of localized pressure from crutch shoulder pads.
  • This localized pigmentary change was observed after treatment with intravenous cisplatin, doxorubicin, and methotrexate.

Findings:

  • Cisplatin is identified as the primary causative agent for the observed skin hyperpigmentation.

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  • Localized pressure appears to potentiate cisplatin-induced hyperpigmentation.
  • Doxorubicin and methotrexate were excluded as contributing factors in this case.

    • Implications:

    • Cisplatin-induced hyperpigmentation may be influenced by external pressure.
    • Understanding the mechanism of cisplatin's effect on melanocytes is crucial.
    • This finding highlights the importance of considering localized pressure in chemotherapy-related dermatological side effects.