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Related Experiment Videos

Right ventricular diastolic dysfunction in heart failure

C M Yu1, J E Sanderson, S Chan

  • 1Cardiology Division, Department of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital.

Circulation
|April 15, 1996
PubMed
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This summary is machine-generated.

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Right ventricular (RV) diastolic dysfunction is common in heart failure (HF) and pulmonary hypertension (PHT), often unrelated to pulmonary artery pressure alone. Further assessment of RV diastolic function in HF prognosis is needed.

Area of Science:

  • Cardiology
  • Echocardiography
  • Heart Failure Research

Background:

  • Left ventricular (LV) diastolic dysfunction is a known predictor in heart failure (HF).
  • Right ventricular (RV) diastolic function has received less attention despite its clinical relevance.
  • This study investigates RV diastolic function in HF patients compared to pulmonary hypertension (PHT) and normal subjects.

Purpose of the Study:

  • To compare right ventricular (RV) diastolic function in patients with heart failure (HF) against those with pulmonary hypertension (PHT) and healthy controls.
  • To determine the prevalence of RV diastolic abnormalities in HF and PHT.
  • To explore the relationship between RV diastolic parameters and pulmonary artery systolic pressure.

Main Methods:

  • Two-dimensional Doppler echocardiography was used to assess transtricuspid and pulmonary artery flow.

Related Experiment Videos

  • 185 subjects were studied: 114 HF patients, 31 PHT patients, and 40 normal subjects.
  • RV diastolic parameters including E-A ratios, peak E-wave velocity, and isovolumic relaxation time were analyzed.

    • Main Results:

    • A high prevalence of RV diastolic abnormalities was observed in both HF (55% with low E-A ratios, 61% with prolonged isovolumic relaxation time) and PHT groups (69% with low E-A ratios, 58% with prolonged isovolumic relaxation time).
    • RV diastolic parameters correlated with pulmonary artery systolic pressure in the PHT group.
    • In HF patients, RV diastolic dysfunction was present even with normal pulmonary artery systolic pressures, and correlated with LV diastolic parameters.

    Conclusions:

    • Right ventricular (RV) diastolic dysfunction is frequent in heart failure (HF) and is not solely due to elevated pulmonary artery systolic pressure.
    • Pulmonary hypertension itself is associated with impaired RV diastolic function.
    • The role of RV diastolic function in HF symptoms and prognosis requires further investigation.