Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Evaluation and management of the solid thyroid nodule

H B Burch1

  • 1Kyle Metabolic Unit, Department of Medicine Walter Reed Army Medical Center, Washington, DC, USA.

Endocrinology and Metabolism Clinics of North America
|December 1, 1995
PubMed
Summary

Managing solid thyroid nodules requires better strategies to avoid unnecessary surgeries for benign lesions. Research is exploring molecular markers and reassessing treatments like thyroid hormone suppressive therapy for improved patient outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A 2013 European survey of clinical practice patterns in the management of Graves' disease.

Clinical endocrinology·2015
Same author

Thyroid cancer yield in patients with Graves' disease.

Minerva endocrinologica·2003
Same author

Nuclear localization of thyroid transcription factor-1 correlates with serum thyrotropin activity and may be increased in differentiated thyroid carcinomas with aggressive clinical course.

Annals of clinical and laboratory science·2001
Same author

Serum thyroglobulin measurement. Utility in clinical practice.

Endocrinology and metabolism clinics of North America·2001
Same author

The effect of antithyroid drug pretreatment on acute changes in thyroid hormone levels after (131)I ablation for Graves' disease.

The Journal of clinical endocrinology and metabolism·2001
Same author

Expression of the sodium iodide symporter and thyroglobulin genes are reduced in papillary thyroid cancer.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc·2001

Area of Science:

  • Endocrinology
  • Oncology
  • Diagnostic Medicine

Background:

  • Solid thyroid nodules are common, posing diagnostic challenges for malignancy detection.
  • Current management strategies aim for safety and cost-effectiveness but face limitations.
  • Over-treatment of benign nodules and reliance on less informative diagnostic methods persist.

Purpose of the Study:

  • To review current challenges and advancements in managing solid thyroid nodules.
  • To highlight the need for improved diagnostic accuracy and treatment strategies.
  • To explore emerging molecular markers for distinguishing malignant from benign nodules.

Main Methods:

  • Review of historical and physical examination features suggestive of malignancy.
  • Evaluation of noninvasive diagnostic techniques.

Related Experiment Videos

  • Assessment of the utility and risks of thyroid hormone suppressive therapy.
  • Exploration of novel molecular markers for nodule characterization.

    • Main Results:

    • Despite progress, many patients undergo thyroidectomy for benign lesions.
    • Routine scintillation scanning and suppressive therapy trials have limited clinical utility.
    • Thyroid hormone suppressive therapy shows limited benefit and potential harm.
    • Molecular markers represent a promising, albeit nascent, area for improved diagnosis.

    Conclusions:

    • Continued efforts are needed to refine management strategies for solid thyroid nodules.
    • Minimizing unnecessary surgeries for benign nodules remains a key objective.
    • Emerging molecular markers and reassessment of existing therapies offer future directions for optimizing patient care.