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Fatigue in MS is associated with specific clinical features
C Colosimo1, E Millefiorini, M G Grasso
1Department of Neurological Sciences, University La Sapienza, Rome, Italy.
Acta Neurologica Scandinavica
|November 1, 1995
Summary
Fatigue is a common symptom in multiple sclerosis (MS). This study found that MS fatigue is more likely in patients with greater disability, progressive disease, older age, and during spring.
Area of Science:
- Neurology
- Clinical Research
Background:
- Fatigue is a prevalent and debilitating symptom in multiple sclerosis (MS).
- Understanding the factors associated with MS fatigue is crucial for patient management.
Purpose of the Study:
- To investigate the association between fatigue and various demographic and clinical characteristics in patients with MS.
Main Methods:
- A survey of 507 clinically definite MS patients was conducted.
- A brief fatigue questionnaire was administered.
- Logistic regression analysis was used to assess associations with demographic and clinical factors, including the Expanded Disability Status Scale (EDSS).
Main Results:
- Fatigue was present in 53% of MS patients.
- Higher disability, progressive MS forms (primary and secondary), older age at examination, and assessment during spring were significantly associated with increased fatigue risk.
- Fatigue was linked to cerebellar, sphincteric, pyramidal, and sensory impairments but not brainstem, visual, or cognitive issues. Sex was not a significant factor.
Conclusions:
- Fatigue in MS is not randomly distributed but is more frequent in conjunction with specific clinical indicators.
- Identifying these clinical features can aid in recognizing and potentially managing fatigue in MS patients.