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Synthesis and characterization of iodixanol
Acta Radiologica. Supplementum
|January 1, 1995
Summary
Iodixanol (Visipaque) is a novel nonionic roentgen contrast agent that is isotonic with blood. Researchers detailed two synthetic pathways and confirmed its chemical structure using various spectroscopic methods.
Area of Science:
- Radiology and Pharmaceutical Chemistry
Background:
- Iodixanol (Visipaque) represents a new class of nonionic roentgen contrast media.
- Its formulation is designed to be isotonic and iso-osmotic with blood, enhancing patient compatibility.
Purpose of the Study:
- To describe two synthetic routes for producing iodixanol.
- To confirm the chemical structure and characterize the chromatographic properties of iodixanol.
Main Methods:
- Two distinct synthetic pathways from 5-nitro-isophthalic acid to iodixanol were developed.
- Spectroscopic techniques including 1H-NMR, 13C-NMR, FAB-MS, UV, IR, and Raman were employed for structural confirmation.
- Chromatographic methods were utilized to analyze the isomerism of iodixanol.
Main Results:
- Successful synthesis of iodixanol via two described routes.
- Confirmation of the chemical structure through comprehensive spectroscopic analysis.
- Characterization of chromatographic properties linked to iodixanol's isomerism.
Conclusions:
- The study successfully outlines the synthesis and structural verification of iodixanol.
- The findings support the development of iodixanol as a safe and effective nonionic roentgen contrast medium.