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Formulation, stability and compatibility of iodixanol
1Research and Development, Nycomed Imaging AS, Oslo Norway.
Acta Radiologica. Supplementum
|January 1, 1995
Summary
Iodixanol (Visipaque) is a stable, isotonic contrast medium for intravascular use. It demonstrates good efficacy, safety, and compatibility with commonly used drugs, ensuring a shelf-life of at least 36 months.
Area of Science:
- Radiology
- Medical Imaging
- Pharmacology
Background:
- Iodixanol (Visipaque) is an established isotonic, electrolyte-balanced contrast medium.
- Its formulation is patented and has a proven track record for intravascular applications.
Purpose of the Study:
- To describe the formulation and rationale behind iodixanol.
- To document the efficacy and safety of iodixanol.
- To assess the stability and in vitro compatibility of iodixanol.
Main Methods:
- Review of formulation, efficacy, and safety data.
- Stability testing under various storage conditions (temperature, container type).
- In vitro testing for drug compatibility.
Main Results:
- Iodixanol exhibits excellent stability in glass and polypropylene bottles, with a shelf-life of at least 36 months at room temperature.
- Heating to body temperature does not compromise product quality.
- No immediate in vitro incompatibilities were observed with frequently co-administered drugs.
Conclusions:
- Iodixanol is a stable and safe contrast medium with a long shelf-life.
- Its formulation is well-suited for intravascular use.
- Iodixanol demonstrates good compatibility with other medications used during contrast examinations.