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Impact of ambulatory blood pressure on left ventricular diastolic dysfunction in uncomplicated arterial systemic

M Galderisi1, A Petrocelli, A Alfieri

  • 1Laboratory of Echocardiography, Clinical Methodology, Medical School, University Federico II of Naples, Italy.

The American Journal of Cardiology
|March 15, 1996
PubMed

Insights

Left ventricular diastolic function is linked to 24-hour blood pressure (BP) patterns. Impaired diastolic filling correlates with higher nighttime BP, highlighting ambulatory BP monitoring

Area of Science:

  • Cardiology
  • Hypertension Research
  • Echocardiography

Background:

  • Left ventricular (LV) diastolic dysfunction is a key indicator of cardiac health.
  • Understanding the relationship between blood pressure (BP) patterns and diastolic filling is crucial for cardiovascular risk assessment.

Purpose of the Study:

  • To investigate the association between 24-hour ambulatory blood pressure (BP) and left ventricular (LV) diastolic filling.
  • To identify specific BP phases and parameters that predict impaired diastolic function.

Main Methods:

  • 125 subjects without cardiac conditions or diabetes underwent Doppler echocardiography and 24-hour ambulatory BP monitoring.
  • Subjects were categorized based on the peak early to atrial velocity (E/A) ratio, indicating normal or impaired diastolic filling.
  • Multivariate analysis was used to identify independent predictors of the E/A ratio.

Main Results:

  • Impaired diastolic filling (E/A <1) was associated with older age, higher LV mass, and elevated average 24-hour and nighttime BP.
  • The E/A ratio showed negative correlations with age, heart rate, office BP, 24-hour BP, nighttime BP, and LV mass index.
  • Age, nighttime BP, and heart rate were independent predictors of impaired LV diastolic filling.

Conclusions:

  • Left ventricular diastolic function is more strongly associated with ambulatory BP measurements than with clinic BP.
  • Elevated average nocturnal diastolic blood pressure is a significant marker for left ventricular filling impairment.
  • Ambulatory BP monitoring provides valuable insights into cardiovascular health beyond traditional clinical measures.

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