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Lidocaine plasma concentrations in pediatric patients after providing airway topical anesthesia from a calibrated

P Sitbon1, M Laffon, V Lesage

  • 1Department of Pediatric Anesthesiology, University Hospital of Tours, France.

Anesthesia and Analgesia
|May 1, 1996
PubMed

Insights

Laryngeal spray with 5% lidocaine is safe for infants and children undergoing airway procedures. This study found plasma lidocaine concentrations remained within safe limits after administration.

Area of Science:

  • Pediatric Anesthesiology
  • Pharmacokinetics
  • Airway Management

Background:

  • Lidocaine is commonly used for local anesthesia during airway procedures.
  • Data on plasma lidocaine concentrations after laryngeal spray in pediatric patients is limited.
  • Ensuring safe anesthetic practices in infants and children is crucial.

Purpose of the Study:

  • To evaluate plasma lidocaine concentrations in pediatric patients following laryngeal spray.
  • To determine the safety and efficacy of 5% lidocaine spray for airway procedures in children.

Main Methods:

  • Prospective study involving 21 pediatric patients (3-24 months) undergoing laryngoscopy or bronchoscopy.
  • Lidocaine administered via 5% spray (0.9-2.6 mg/kg) after mask induction with halothane.
  • Plasma lidocaine concentrations measured to determine maximum concentration (Cmax).

Main Results:

  • Maximum plasma lidocaine concentration (Cmax) averaged 1.05 +/- 0.55 micrograms/mL (range: 0.24-2.29 micrograms/mL).
  • Doses administered ranged from 0.9 to 2.6 mg/kg.
  • Observed concentrations were within established safe limits for lidocaine.

Conclusions:

  • Laryngeal spray administration of 5% lidocaine is a safe method for pediatric patients.
  • The evaluated doses and resulting plasma concentrations support the safety of this technique.
  • This study provides valuable pharmacokinetic data for pediatric airway management.

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