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Antigen-presenting function of the mouse CD1 molecule

S Tangri1, H R Holcombe, A R Castaño

  • 1Department of Microbiology and Immunology, University of California, Los Angeles, 90095-1570, USA.

Annals of the New York Academy of Sciences
|February 13, 1996
PubMed
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Mouse CD1 molecules present longer peptides than MHC class I, binding bulky hydrophobic amino acids. These CD1-restricted T cells suggest a role in mucosal immunity and oral tolerance.

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • CD1 molecules are related to MHC class I and coexpressed with beta2 microglobulin (beta2m).
  • Mouse CD1 (mCD1) is found on intestinal epithelial cells, spleen, and lymph node cells.
  • mCD1 surface expression is independent of the transporter associated with antigen processing (TAP).

Purpose of the Study:

  • To investigate the peptide-binding characteristics of mouse CD1 (mCD1) molecules.
  • To determine the immunologic relevance of mCD1-peptide interactions.
  • To explore the potential role of mCD1 in mucosal immunity and oral tolerance.

Main Methods:

  • Analysis of mCD1 surface expression and TAP independence.
  • Characterization of mCD1 peptide-binding motifs, focusing on peptide length and amino acid properties.

Related Experiment Videos

  • Generation and characterization of mCD1-restricted and peptide-specific T-cell lines.

    • Main Results:

    • mCD1 binds peptides significantly longer than the 8-9 amino acids typical for classical class I molecules.
    • mCD1 peptide binding is characterized by a motif favoring bulky and hydrophobic amino acid side chains.
    • Generated T-cell receptor (TCR) alphabeta+ CD8+ T-cell lines specific for mCD1-presented peptides, demonstrating immunologic relevance.

    Conclusions:

    • mCD1 molecules present distinct peptides compared to classical class I molecules, potentially acquiring them in a non-endoplasmic reticulum compartment.
    • mCD1 may sample peptides from the gut lumen and present them to mucosal T lymphocytes.
    • mCD1 molecules could play a crucial role in maintaining mucosal homeostasis and inducing oral tolerance.