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Related Experiment Videos

Myocardial stimulation by pancuronium bromide

R F Seed, J H Chamberlain

    British Journal of Anaesthesia
    |May 1, 1977
    PubMed
    Summary

    Pancuronium bromide increased heart rate and myocardial contractility in dogs. This neuromuscular blocking agent enhanced cardiac function, particularly after denervation and pacing.

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    Area of Science:

    • Pharmacology
    • Cardiovascular Physiology
    • Anesthesiology

    Background:

    • Pancuronium bromide is a neuromuscular blocking agent.
    • Its effects on myocardial contractility require further investigation.

    Purpose of the Study:

    • To investigate the effects of pancuronium bromide on canine myocardial contractility.
    • To assess cardiac responses to intravenous and intracoronary administration.

    Main Methods:

    • Anesthetized, open-chested dogs were used.
    • Pancuronium bromide was administered intravenously and intracoronarily.
    • Myocardial contractility indices were measured, including aortic blood flow and dP/dt.

    Main Results:

    • Pancuronium bromide induced tachycardia with both administration routes.
    • Intracoronary infusion, after denervation and pacing, increased aortic blood flow and dP/dt.
    • These effects were transient, resolving within 5 minutes after cessation.

    Conclusions:

    • Pancuronium bromide exhibits positive inotropic effects on the canine myocardium.
    • The drug's impact on cardiac function is dose- and administration-route dependent.

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