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Ca2+ entry modulates oscillation frequency by triggering Ca2+ release

T J Shuttleworth1, J L Thompson

  • 1Department of Physiology, University of Rochester School of Medicine and Dentistry, NY 14642, USA.

The Biochemical Journal
|February 1, 1996
PubMed
Summary
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Calcium oscillations in avian nasal gland cells depend on calcium entry, not store refilling. The rate of calcium entry directly influences oscillation frequency by triggering calcium release, challenging existing models.

Area of Science:

  • Cellular Physiology
  • Calcium Signaling

Background:

  • Agonist-induced cytosolic Ca2+ concentration ([Ca2+]1) oscillations are crucial in many cell types.
  • The frequency of these oscillations is known to be influenced by the rate of Ca2+ entry.

Purpose of the Study:

  • To investigate the mechanism underlying the dependence of Ca2+ oscillation frequency on Ca2+ entry rate in exocrine avian nasal gland cells.
  • To challenge and refine current models of Ca2+ oscillation.

Main Methods:

  • Experimental analysis of agonist-induced Ca2+ oscillations.
  • Measurement of cytosolic Ca2+ concentration ([Ca2+]1) dynamics.
  • Investigation of the role of Ca2+ stores and Ca2+ entry in oscillation initiation and frequency.

Main Results:

Related Experiment Videos

  • Oscillation initiation is independent of store fullness.
  • The oscillating Ca2+ pool is fully refilled by the end of each spike.
  • The interspike interval does not reflect store refilling time.

Conclusions:

  • Ca2+ entry rate influences oscillation frequency by triggering repetitive Ca2+ release, not by refilling stores.
  • Current models suggesting store refilling as the primary determinant of frequency are challenged.
  • The role of Ca2+ entry in triggering Ca2+ release is the key mechanism for frequency modulation.