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Related Experiment Videos

Amyloidosis developing in experimental nocardia infections

P I Folb, A Horowitz, M Greenwald

    British Journal of Experimental Pathology
    |April 1, 1977
    PubMed
    Summary

    Swiss white and C57/BL/6J mice developed amyloidosis after Nocardia inoculation. Genetic factors in these mouse strains appear crucial for secondary amyloidosis development.

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    Area of Science:

    • Microbiology
    • Immunology
    • Pathology

    Background:

    • Amyloidosis is a group of diseases characterized by the deposition of amyloid proteins.
    • Secondary amyloidosis can arise from chronic inflammatory conditions.
    • The role of specific bacterial infections in inducing amyloidosis requires further investigation.

    Purpose of the Study:

    • To investigate the potential of Nocardia asteroides and Nocardia brasiliensis to induce amyloidosis in mice.
    • To explore the influence of host genetics on the development of Nocardia-induced secondary amyloidosis.

    Main Methods:

    • Swiss white and C57/BL/6J mice were inoculated with Nocardia asteroides or Nocardia brasiliensis.
    • Inoculations were performed repeatedly over 7 months or as a single large dose.
    • Control groups included other in-bred mouse strains.

    Main Results:

    • Both Swiss white and C57/BL/6J mice developed amyloidosis following repeated Nocardia inoculations.
    • Amyloidosis was also observed in these strains after a single large Nocardia inoculum.
    • Other in-bred mouse strains did not develop amyloidosis under similar conditions.

    Conclusions:

    • Nocardia asteroides and Nocardia brasiliensis can induce secondary amyloidosis in susceptible mouse strains.
    • Genetic predisposition plays a significant role in the pathogenesis of Nocardia-induced amyloidosis.

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