From genes to mechanisms to therapies: lessons to be learned from neurological disorders

Polyallelic structural variants can provide accurate, highly informative genetic markers focused on diagnosis and therapeutic targets: Accuracy vs. Precision.

Clinical pharmacology and therapeutics·2015

Are APOE ɛ genotype and TOMM40 poly-T repeat length associations with cognitive ageing mediated by brain white matter tract integrity?

Translational psychiatry·2014

Polymorphism in the TOMM40 gene modifies the risk of developing sporadic inclusion body myositis and the age of onset of symptoms.

Neuromuscular disorders : NMD·2013

Inhibition of α-ketoglutarate-and pyruvate dehydrogenase complexes in E. coli by a glutathione S-transferase containing a pathological length poly-Q domain: A possible role of energy deficit in neurological diseases associated with poly-Q expansions?

Age·2013

Using genetics to enable studies on the prevention of Alzheimer's disease.

Clinical pharmacology and therapeutics·2012

A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing.

Molecular psychiatry·2012

Urine cell-free RNA for bladder cancer detection and treatment response prediction.

Nature medicine·2026

Small quantity lipid-based nutritional supplementation and measles vaccination coverage in children aged 6-23 months: a pragmatic cluster-randomized trial.

Nature medicine·2026

Five-year survival with neoadjuvant therapy in melanoma: updated pooled analysis from the International Neoadjuvant Melanoma Consortium (INMC).

Nature medicine·2026

Effects of semaglutide on kidney disease in type 2 diabetes: a randomized placebo-controlled trial.

Nature medicine·2026

Intravenous hyaluronidase-expressing oncolytic adenovirus with chemotherapy in metastatic pancreatic cancer: a randomized phase 2b trial.

Nature medicine·2026

Reproducibility in biomedical research.

Nature medicine·2026

When the Electromyography (EMG) and the Patient Disagree: Unraveling a Motor Neuron Disease Mimic With Small-Fiber Dysfunction.

Cureus·2026

Human iPSC-Derived Tissue-Engineered Nigrostriatal Pathway for Chronic Restoration of Dopaminergic Axon Tracts in a Rat Parkinson's Model.

Advanced healthcare materials·2026

Increased CCR2-immunopositive myeloid cells in the putamen and cerebellar white matter with blood-brain barrier disruption in multiple system atrophy.

Neuroscience letters·2026

Loss of Cotl1 disrupts mitochondrial fission and impairs learning and memory in mice.

Life sciences·2026

Polydatin Encapsulated in Human Serum Albumin Nanoparticles Attenuates Oxidative Damage and Protects Rotenone-Induced Neuroblastoma cells.

European journal of pharmacology·2026

Comparative quantitative analysis of choroidal abnormalities in patients with type 1 neurofibromatosis using multimodal retinal imaging.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie·2026

Related Experiment Videos

From genes to mechanisms to therapies: lessons to be learned from neurological disorders

Related Concept Videos

Polyallelic structural variants can provide accurate, highly informative genetic markers focused on diagnosis and therapeutic targets: Accuracy vs. Precision.

Are APOE ɛ genotype and TOMM40 poly-T repeat length associations with cognitive ageing mediated by brain white matter tract integrity?

Polymorphism in the TOMM40 gene modifies the risk of developing sporadic inclusion body myositis and the age of onset of symptoms.

Inhibition of α-ketoglutarate-and pyruvate dehydrogenase complexes in E. coli by a glutathione S-transferase containing a pathological length poly-Q domain: A possible role of energy deficit in neurological diseases associated with poly-Q expansions?

Using genetics to enable studies on the prevention of Alzheimer's disease.

A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing.

Urine cell-free RNA for bladder cancer detection and treatment response prediction.

Small quantity lipid-based nutritional supplementation and measles vaccination coverage in children aged 6-23 months: a pragmatic cluster-randomized trial.

Five-year survival with neoadjuvant therapy in melanoma: updated pooled analysis from the International Neoadjuvant Melanoma Consortium (INMC).

Effects of semaglutide on kidney disease in type 2 diabetes: a randomized placebo-controlled trial.

Intravenous hyaluronidase-expressing oncolytic adenovirus with chemotherapy in metastatic pancreatic cancer: a randomized phase 2b trial.

Reproducibility in biomedical research.

When the Electromyography (EMG) and the Patient Disagree: Unraveling a Motor Neuron Disease Mimic With Small-Fiber Dysfunction.

Human iPSC-Derived Tissue-Engineered Nigrostriatal Pathway for Chronic Restoration of Dopaminergic Axon Tracts in a Rat Parkinson's Model.

Increased CCR2-immunopositive myeloid cells in the putamen and cerebellar white matter with blood-brain barrier disruption in multiple system atrophy.

Loss of Cotl1 disrupts mitochondrial fission and impairs learning and memory in mice.

Polydatin Encapsulated in Human Serum Albumin Nanoparticles Attenuates Oxidative Damage and Protects Rotenone-Induced Neuroblastoma cells.

Comparative quantitative analysis of choroidal abnormalities in patients with type 1 neurofibromatosis using multimodal retinal imaging.

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From genes to mechanisms to therapies: lessons to be learned from neurological disorders

Related Concept Videos

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