Polyalanylation of bovine somatotropin peptide 96-133

Polyalanylation of bovine somatotropin peptide 96-133 has been investigated. Polyalanylated peptides contained an average of 3-50 additional alanines per mole of peptide. As indicated by circular dichroism, the parent peptide and the polyalanylated peptides were helical at pH 4.0. The biological activity per mole of peptide with 50 additional alanies was approximately the same as that of the parent peptide.