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Related Experiment Videos

Attempts to convert chymotrypsin to trypsin

I Venekei1, L Szilágyi, L Gráf

  • 1University of California, San Francisco, Hormone Research Institute, USA.

FEBS Letters
|March 25, 1996
PubMed
Summary

Converting chymotrypsin to trypsin specificity is complex. Mutating key sites, including Asp189, only partially altered specificity and reduced enzyme activity, indicating more mutations are needed.

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Area of Science:

  • Biochemistry
  • Enzymology
  • Protein Engineering