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Published on: December 23, 2010
Hyaluronan-binding properties of human serum hemopexin
Z Hrkal1, K Kuzelová, U Muller-Eberhard
1Department of Cellular Biochemistry, Institute of Hematology and Blood Tranfusion, Prague, Czech Republic.
Abstract:
Hemopexin, the heme-binding serum glycoprotein, exhibits a complex electrophoretic pattern on two-dimensional immunoelectrophoresis on agarose gels into which hyaluronic acid is incorporated in the first and monospecific anti-hemopexin in the second dimension. This heterogeneity reflects a range of interactions of hemopexin isoforms with hyaluronic acid. Electrophoretic patterns of individual human sera greatly differ in their contents of hyaluronan-interacting hemopexin species. Hemopexin itself has no hyaluronidase activity.
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