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Published on: March 28, 2018
Risk of primary sclerosing cholangitis is associated with nonsmoking behavior
K J van Erpecum1, S J Smits, P C van de Meeberg
1Department of Gastroenterology, University Hospital Utrecht, The Netherlands.
Smoking is associated with a decreased risk of primary sclerosing cholangitis (PSC). This study found that current smokers were less likely to have PSC, while appendectomy history showed no significant association with PSC risk.
Area of Science:
- Gastroenterology
- Hepatology
- Epidemiology
Background:
- Primary sclerosing cholangitis (PSC) frequently co-occurs with ulcerative colitis.
- Smoking and appendectomy are potential protective factors against ulcerative colitis.
Purpose of the Study:
- To investigate the association between smoking and appendectomy history in patients with PSC.
- To determine if these factors influence the risk of developing PSC.
Main Methods:
- A case-control study involving 59 PSC patients, 130 ulcerative colitis patients, and 197 controls.
- Interviews were conducted to gather data on smoking behavior and appendectomy history.
Main Results:
- Current smokers were less prevalent in PSC (19%) and ulcerative colitis (12%) groups compared to controls (38%).
- Odds ratio for current smoking was 0.37 in PSC and 0.23 in ulcerative colitis.
- Appendectomy frequency did not differ significantly between PSC, ulcerative colitis, and control groups.
Conclusions:
- Smoking is significantly associated with a reduced risk of primary sclerosing cholangitis.
- Previous appendectomy does not appear to be associated with a decreased risk of PSC.
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