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Related Experiment Videos

Infected-associated hemophagocytic syndrome

Z E Currimbhoy1

  • 1Department of Pediatric Hematology and Oncology, B.J. Wadia Hospital for Children, Parel, Bombay.

Indian Pediatrics
|March 1, 1995
PubMed
Summary
This summary is machine-generated.

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A novel infection involving hemophagocytes (HP) and activated monocytes (AM) affected children in Bombay. This distinct condition presented with fever, neurological symptoms, and bleeding, differing from known hemophagocytic syndromes.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Hematology

Background:

  • An epidemic of a novel infection characterized by circulating hemophagocytes (HP) and activated monocytes (AM) occurred in Bombay.
  • The condition presented distinct features overlapping with, yet separate from, virus-associated hemophagocytic syndrome and familial hemophagocytic lymphohistiocytosis.

Purpose of the Study:

  • To describe the clinical and laboratory features of this distinct hemophagocytic syndrome in children.
  • To categorize the affected children into distinct groups based on age and clinical presentation.

Main Methods:

  • Observational study of children presenting with the novel infection in Bombay.
  • Clinical assessment including age, symptoms, neurological status, and bleeding.
  • Laboratory investigations including blood smears, coagulation profiles, and biochemical tests.

Related Experiment Videos

  • Subgroup analysis based on age (neonates, infants, children) and surgical cases with small bowel malformations.

    • Main Results:

    • Affected children (2 days to 2 years) exhibited fever, altered sensorium, neurological symptoms, dyspnea, diarrhea, and significant bleeding.
    • Key laboratory findings included neutrophilia, presence of AM and HP in blood smears, coagulopathy, normal CSF and liver transaminases, hypertriglyceridemia, and hypoalbuminemia.
    • Surgical cases were associated with small bowel malformations. Four distinct clinical groups were identified: neonates, infants, children, and surgical.

    Conclusions:

    • A distinct epidemic infection involving hemophagocytes and activated monocytes occurred in Bombay, primarily affecting young children.
    • The condition presents with a unique constellation of symptoms and laboratory findings, necessitating its classification separate from established hemophagocytic syndromes.
    • Clinical presentation and outcomes vary significantly across different age groups and in surgical cases with gastrointestinal anomalies.