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Related Experiment Videos

Testing compliance of drug taking--a simple bed side method

N Thilothammal1, P V Krishnamurthy, K Banu

  • 1Clinical Epidemiology Unit, Institute of Child Health, Indian Council of Medical Research, Madras.

Indian Pediatrics
|March 1, 1995
PubMed
Summary

Assessing patient adherence to medication is crucial. Riboflavin as a urinary marker, detected by UV light or torch, offers a reliable method for compliance assessment, particularly the UV lamp technique.

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Area of Science:

  • Pharmacology and Therapeutics
  • Clinical Diagnostics
  • Public Health

Background:

  • Patient compliance with prescribed medication regimens is a significant challenge in outpatient settings.
  • Riboflavin, a vitamin, can serve as a urinary marker to objectively assess drug intake.
  • Detection of urinary riboflavin via fluorescence under ultraviolet (UV) or torch light is a potential compliance monitoring tool.

Purpose of the Study:

  • To evaluate the validity and reliability of using riboflavin as a urinary marker for assessing drug compliance.
  • To compare the accuracy of UV light versus torch light methods for detecting urinary riboflavin fluorescence.
  • To assess the agreement between medical and paramedical personnel in interpreting fluorescence results.

Main Methods:

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  • A study was conducted to assess compliance using riboflavin as a urinary marker.
  • Fluorescence detection of riboflavin in urine was performed using both UV lamp and torch light.
  • Sensitivity, specificity, and accuracy were calculated for each method and reader (medical vs. paramedical).

    • Main Results:

    • The UV method demonstrated good sensitivity and specificity for both readers (e.g., 86% sensitivity, 82% specificity for Reader I).
    • Accuracy for Reader I was similar between UV lamp (85%) and torch light (85%), while Reader II showed higher accuracy with UV (87%) than torch (79%).
    • Inter-reader agreement for UV lamp fluorescence detection was 82% crude agreement and 64% chance-corrected agreement.

    Conclusions:

    • The UV lamp method is a reliable approach for assessing drug compliance, suitable for both medical and paramedical staff.
    • The torch light method's reliability is more dependent on the reader, being more effective with medical personnel.
    • Riboflavin fluorescence detection presents a practical and valid strategy for monitoring patient adherence in clinical practice.