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Peptide epitopes from noncytosolic Listeria monocytogenes can be presented by major histocompatibility complex class
1Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206-2761, USA.
Infection and Immunity
|May 1, 1996
Abstract:
Listeria monocytogenes is an intracellular pathogen which escapes the phagosome and resides in the cytosol of the host cell. Using Listeria innocua and a mutant strain of L. monocytogenes (listeriolysin O negative), which do not enter the cytosol of the host cell, we demonstrate class I presentation of an epitope of p60, a protein secreted by L. monocytogenes, to a class I-restricted CD8+ cytotoxic T lymphocyte clone.