Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

The antiphospholipid-protein syndrome

D B Cines¹, K R McCrae

¹Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia 19104, USA.

Journal of Clinical Immunology

|November 1, 1995

Summary

Antiphospholipid syndrome pathogenesis is unclear. Autoantibodies may target lipid-protein complexes, contributing to diverse symptoms and necessitating better diagnostic tools for thrombosis and abortion risk.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

In vitro characterization of SynthoPlate™ (synthetic platelet) technology and its in vivo evaluation in severely thrombocytopenic mice.

Journal of thrombosis and haemostasis : JTH·2016

Same author

A novel pathway of cellular activation mediated by antiphospholipid antibody-induced extracellular vesicles.

Journal of thrombosis and haemostasis : JTH·2015

Same author

Heparin enhances uptake of platelet factor 4/heparin complexes by monocytes and macrophages.

Journal of thrombosis and haemostasis : JTH·2015

Same author

Rituximab for treatment of inhibitors in haemophilia A. A Phase II study.

Thrombosis and haemostasis·2014

Same author

Clot penetration and retention by plasminogen activators promote fibrinolysis.

Biochemical pharmacology·2012

Same author

Interaction of high-molecular-weight kininogen with endothelial cell binding proteins suPAR, gC1qR and cytokeratin 1 determined by surface plasmon resonance (BiaCore).

Thrombosis and haemostasis·2011

Area of Science:

Immunology
Rheumatology
Pathogenesis of autoimmune diseases

Background:

The exact cause of antiphospholipid syndrome (APS) is unknown.
Antibodies to phospholipids may not directly cause cell damage but are part of a broader immune response.
Pathogenic autoantibodies in APS might target various molecules, including lipid-protein complexes.

Purpose of the Study:

To explore the complex immunological network in antiphospholipid syndrome.
To understand the role of autoantibodies targeting various lipid-protein complexes.
To highlight the need for improved diagnostic methods for identifying patients at risk.

Main Methods:

Review of current understanding of antiphospholipid syndrome pathogenesis.
Analysis of potential autoantibody targets including beta 2-glycoprotein I complexes, protein C, and oxidized low-density lipoproteins.
Discussion of limitations in current diagnostic techniques.

Main Results:

A spectrum of autoantibodies recognizing different lipid-protein complexes may develop in APS patients.
These autoantibodies can contribute to the clinical heterogeneity observed in APS.
Current methods cannot reliably identify APS patients at high risk for thrombosis or pregnancy loss.

Conclusions:

Understanding the specific cellular targets of autoantibodies is crucial for risk stratification in APS.
Identification of these targets is essential for developing effective monitoring and therapeutic strategies.
Further research is needed to refine diagnostic and prognostic tools for antiphospholipid syndrome.

Related Experiment Videos