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Published on: November 4, 2010
Decrease in hospitalization for treatment of childhood asthma with increased use of antiinflammatory treatment,
G Wennergren1, S Kristjánsson, I L Strannegård
1Department of Pediatrics, University of Göteborg, Ostra Hospital, Sweden.
Insights
Childhood asthma hospitalizations decreased significantly due to inhaled steroid treatment. This anti-inflammatory approach proved highly effective and cost-efficient for pediatric asthma management.
Area of Science:
- Pediatric Pulmonology
- Public Health
- Pharmacotherapy
Background:
- Asthma prevalence in Swedish children doubled over 15 years.
- Inhaled steroid anti-inflammatory treatment increased concurrently since 1985.
Purpose of the Study:
- To evaluate the impact of increased inhaled steroid use on pediatric asthma hospitalizations.
- To analyze trends in hospital days and admissions for childhood asthma.
Main Methods:
- Population-based study in Göteborg, Sweden (0.5 million inhabitants).
- Data collected on hospital days, admissions, and individual patients for acute asthma (1985-1993).
- Centralized inpatient care at a single children's hospital; consistent hospitalization policies.
Main Results:
- Significant decrease in hospital days (to <1/3) and admissions (by 45%) for children aged 2-18 years.
- Most pronounced reduction in older children (>5 years): hospital days reduced to 1/5, admissions halved.
- Decreasing trend in hospital days observed in 2-5 year olds; no significant trend in individual patient admissions.
Conclusions:
- Inhaled steroids are the primary driver for reduced pediatric asthma hospitalizations (ages 2-18).
- Parent/patient education may be a contributing factor.
- Anti-inflammatory treatment with inhaled steroids is a cost-effective strategy for pediatric asthma.
Background:
During the past 15 years, the prevalence of asthma in children in Sweden has doubled. However, since 1985, antiinflammatory treatment with inhaled steroids has increased continuously.
Objective:
The aim of this study was to analyze the net effect of these changes in terms of hospitalization of children for treatment of asthma.
Methods:
The numbers of hospital days, admissions, and individual patients admitted to the Children's Hospital in Göteborg because of acute asthma were recorded from 1985 through 1993. all the in-patient treatment of children is centralized at this hospital (i.e., the study was population-based). Göteborg has half a million inhabitants. Hospitalization policies were not altered during the study period.
Results:
In children aged 2 to 18 years, the number of hospital days per year gradually decreased to less than a third (r = 0.9; p less than 0.001), and admissions decreased by 45% (r = 0.7; p less than 0.05). The decrease in hospitalization was most marked in the group older than the age of 5 years in which hospital days were reduced to one fifth (r = 0.9; p less than 0.0001) and admissions were halved (r = 0.8; p less than 0.05). A decreasing trend in number of hospital days was also seen in the 2- to 5-year-old group. The number of individual patients admitted did not show a statistically significant decreasing trend. In children under the age of 2 years, the number of hospital days fluctuated, and there was no clear-cut change with time.
Conclusion:
Although increased concentration on the education of parents and patients may have been a contributing factor, the major reason for the decrease in hospitalization in the group of children aged 2 to 18 years is most probably antiinflammatory treatment with inhaled steroids. The results suggest that this is a very cost-effective therapeutic approach.
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