Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Silicone breast implants: immunotoxic and epidemiologic issues

S H Yoshida1, S Swan, S S Teuber

  • 1Division of Rheumatology, Allergy and Clinical Immunology, School of Medicine, University of California, Davis 95616, USA.

Life Sciences
|March 10, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differentiation from thymic B cell progenitors to mature B cells in vitro.

Immunobiology·2000
Same author

Mimicry peptides of human PDC-E2 163-176 peptide, the immunodominant T-cell epitope of primary biliary cirrhosis.

Hepatology (Baltimore, Md.)·2000
Same author

Primary biliary cirrhosis: an orchestrated immune response against epithelial cells.

Immunological reviews·2000
Same author

The peculiar autoimmunity of primary biliary cirrhosis.

Immunological reviews·2000
Same author

Sick building syndrome. III. Stachybotrys chartarum.

The Journal of asthma : official journal of the Association for the Care of Asthma·2000
Same author

Immune-mediated cholangiohepatitis in neonatally thymectomized mice: the role of T cells and analysis of T-cell receptor Vbeta usage.

Journal of autoimmunity·2000

Silicone gel implants can cause local complications and systemic spread of silicone. Limited epidemiologic data exists, necessitating further research into long-term safety and adverse immune effects.

Area of Science:

  • Biomaterials Science
  • Immunology
  • Epidemiology

Background:

  • Silicone gel implants have been used for breast augmentation and reconstruction since 1962.
  • Complications include capsular contracture, rupture, gel bleed, and lymph node spread.
  • Systemic findings include silicon compounds in blood and liver tissue.

Purpose of the Study:

  • To review adverse immune effects associated with silicone contact.
  • To summarize available epidemiologic data on silicone breast implants.
  • To address concerns regarding systemic disease associations.

Main Methods:

  • Review of existing literature on silicone implant complications.
  • Analysis of studies on silicon compound detection in biological samples.

Related Experiment Videos

  • Examination of epidemiologic data and clinical observations.

    • Main Results:

    • Histologic findings show foreign body granulomas in capsular tissue and lymph nodes.
    • Silicon compounds detected in blood and liver of some women with implants.
    • Limited controlled epidemiological studies available since 1992.

    Conclusions:

    • Concerns exist regarding silicone implants and systemic disease, but data is limited.
    • Further research is needed due to the lack of long-term safety data.
    • Regulatory actions in 1992 spurred research into silicone bioreactivity and patient outcomes.