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Updated: Aug 14, 2026

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
Published on: December 9, 2010
Trimethoprim and sulfonamide-associated meningoencephalitis with MRI correlates
H Blumenfeld1, J H Cha, M E Cudkowicz
1Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
Abstract:
Early recognition of trimethoprim and sulfonamide-induced aseptic meningitis is important because drug cessation leads to rapid clinical improvement. We present clinical and laboratory findings in two typical cases. In both cases, MRI revealed previously undescribed diffuse white matter abnormalities that resolved within a few months. These MRI findings are important because they may aid in early diagnosis of this condition in the appropriate clinical setting. In addition, the white matter abnormalities suggest an encephalitic component in addition to the meningitis.
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