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Related Experiment Videos

Chloramphenicol-dependent antibody: a case report

M R Fried1, T L Scofield, D F Stroncek

  • 1Blood Bank, University of Minnesota Hospital and Clinic, Minneapolis, USA.

Transfusion
|February 1, 1996
PubMed
Summary
This summary is machine-generated.

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A rare chloramphenicol-dependent antibody caused interference in blood testing. This IgM antibody required chloramphenicol for serologic reactivity, highlighting the importance of in vivo drug testing.

Area of Science:

  • Immunology
  • Transfusion Medicine
  • Clinical Pathology

Background:

  • Chloramphenicol-dependent antibodies are infrequent causes of interference in pretransfusion serologic tests.
  • Confirmation involves testing red cells with and without chloramphenicol.

Observation:

  • A 29-year-old man presented with a chloramphenicol-dependent panagglutinin in his serum.
  • The IgM antibody (titer 8) lacked blood group specificity and did not react with platelets or granulocytes.

Findings:

  • Standard confirmation methods using chloramphenicol sodium succinate solution yielded negative results.
  • The antibody demonstrated serologic reactivity exclusively in the presence of chloramphenicol, activated by blood esterases.

Implications:

Related Experiment Videos

  • This case underscores the significance of investigating drug-related serologic phenomena.
  • Laboratory diagnostics must consider in vivo drug reactions for accurate antibody detection.