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[Clinical results with granulocyte transfusion (author's transl)]
Medizinische Klinik
|May 4, 1979
Summary
Granulocyte transfusions may benefit patients with severe infections and low white blood cell counts when other treatments fail. These transfusions are indicated for granulocytopenia and sepsis without bone marrow recovery.
Area of Science:
- Hematology
- Transfusion Medicine
- Infectious Diseases
Context:
- Severe infections, particularly sepsis, pose significant risks in patients with granulocytopenia.
- Antibiotic resistance complicates treatment of septicemia, necessitating alternative therapeutic strategies.
- Granulocyte transfusions are a potential supportive therapy for immunocompromised patients.
Purpose:
- To evaluate the efficacy and outcomes of granulocyte transfusions in adult patients suffering from antibiotic-resistant granulocytopenia and septicemia.
Summary:
- Sixteen adult patients with granulocytopenia and septicemia received 42 granulocyte transfusions. Granulocytes were collected using continuous flow centrifugation with hydroxyethyl-starch, yielding an average of 1.8 x 10(10) leukocytes. Half of the recipients showed a minor leukocyte increase post-transfusion.
- No significant correlation was observed between fever lysis and patient survival. Sepsis resolved in approximately half of the treated cases.
- Granulocyte transfusions are recommended for patients with granulocytopenia and sepsis who show no signs of bone marrow recovery.
Impact:
- Granulocyte transfusions represent a viable therapeutic option for a specific subset of critically ill patients.
- This study highlights the importance of considering granulocyte transfusions in refractory cases of sepsis with severe neutropenia.
- Further research may elucidate predictive factors for successful outcomes and optimize transfusion protocols.