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Related Experiment Videos

Copper as an essential nutrient

M Olivares1, R Uauy

  • 1Institute of Nutrition and Food Technology, University of Chile, Santiago.

The American Journal of Clinical Nutrition
|May 1, 1996
PubMed
Summary
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Copper is essential for infant growth, brain development, and enzyme function. Copper deficiency can lead to anemia, neutropenia, and bone issues, impacting overall health.

Area of Science:

  • Biochemistry
  • Human Physiology
  • Nutritional Science

Background:

  • Copper is a vital trace element crucial for numerous physiological processes.
  • It plays a role in enzyme function, infant growth, immune response, and neurological development.
  • Copper deficiency can stem from inherited disorders like Menkes syndrome or acquired conditions, particularly in infants.

Purpose of the Study:

  • To review the multifaceted roles of copper in human health.
  • To outline the clinical manifestations of copper deficiency.
  • To discuss current and potential biomarkers for assessing copper status.

Main Methods:

  • Literature review of animal and human studies on copper's biological functions.
  • Analysis of clinical data and case studies related to copper deficiency.

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  • Evaluation of diagnostic methods for copper status assessment.

    • Main Results:

    • Copper is indispensable for infant growth, host defense, bone health, cell maturation, metabolism, and brain development.
    • Acquired copper deficiency, often seen in malnourished infants, presents with anemia, neutropenia, and bone abnormalities.
    • Marginal copper deficiency may not be adequately detected by serum copper and ceruloplasmin levels.

    Conclusions:

    • Copper is essential for a wide range of critical bodily functions.
    • Clinical signs of copper deficiency are diverse, ranging from anemia to impaired growth and infections.
    • Novel biomarkers like erythrocyte superoxide dismutase and platelet cytochrome c may offer improved detection of marginal copper deficiency.