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Undescribed toxin in pseudomembranous colitis

H E Larson, J V Parry, A B Price

    British Medical Journal
    |May 14, 1977
    PubMed
    Summary
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    A 12-year-old girl developed pseudomembranous colitis after oral penicillin. Her stool contained a toxin, suggesting bacterial toxins may cause this condition.

    Area of Science:

    • Gastroenterology
    • Microbiology
    • Toxicology

    Background:

    • Pseudomembranous colitis is a severe intestinal condition.
    • Antibiotic use is a known risk factor for colitis.

    Observation:

    • A pediatric patient developed pseudomembranous colitis following a course of oral penicillin.
    • No infectious agents were identified in the patient's stool samples.
    • A toxin was detected in the stool of the affected patient.

    Findings:

    • The patient's stool contained a toxin, but pathogenic bacteria, mycoplasmas, or viruses were absent.
    • Toxin presence was confirmed in 4 out of 5 additional pseudomembranous colitis cases.
    • No toxin was found in stool samples from patients with diarrhea due to other causes.

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    Implications:

    • This study suggests a potential link between bacterial toxins and the development of pseudomembranous colitis.
    • Further research is warranted to elucidate the role of specific bacterial toxins in this condition.
    • Findings may inform diagnostic approaches and therapeutic strategies for antibiotic-associated colitis.