Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Peptide models for membrane channels

D Marsh1

  • 1Max-Planck-Institut für biophysikalische Chemie, Abt. Spektroskopie, Göttingen, Federal Republic of Germany.

The Biochemical Journal
|April 15, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Departmental audit on immobilisation in a small cohort of patients with lower limb sarcoma.

Radiography (London, England : 1995)·2025
Same author

A global call to action to improve the care of people with fragility fractures.

Injury·2018
Same author

Low-intensity pulsed ultrasound does not influence bone healing by distraction osteogenesis: a multicentre double-blind randomised control trial.

The bone & joint journal·2017
Same author

EULAR/EFORT recommendations for management of patients older than 50 years with a fragility fracture and prevention of subsequent fractures.

Annals of the rheumatic diseases·2016
Same author

FRAX-based assessment and intervention thresholds--an exploration of thresholds in women aged 50 years and older in the UK.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2015
Same author

Local motion and conformational changes in the cuticle of Clivia miniata Regel : A microfluorescence and spin-label study.

Planta·2013
Same journal

Alternative Splicing of Rice Chloroplastic CuZn Superoxide Dismutase, OsCSD2: Impact on expression and protein characteristics.

The Biochemical journal·2026
Same journal

Difference and similarity between the ubiquitous secretory pathway Ca2+-ATPases, SERCA2b, and SPCA1a.

The Biochemical journal·2026
Same journal

A molecular perspective on dimethylarginine dimethylaminohydrolases structure and function.

The Biochemical journal·2026
Same journal

Proteolytic coordination of the OXPHOS Life Cycle.

The Biochemical journal·2026
Same journal

VDR/RXR antagonizes calcineurin-activated NFAT1, an essential regulator of Coronin-1A expression and Mycobacterial persistence.

The Biochemical journal·2026
Same journal

Bioinformatic assessment of the potential amyloidogenicity of the human and evolutionarily more ancient proteomes.

The Biochemical journal·2026
See all related articles

Synthesized peptides mimicking ion channel domains can form functional channels in lipid bilayers. Understanding their secondary structures and assembly is key to studying ion channel mechanisms.

Area of Science:

  • Biophysics
  • Molecular Biology
  • Membrane Protein Research

Background:

  • Ion channels are crucial for cellular processes.
  • Synthesizing peptides from ion channel structures allows for in vitro studies.
  • Understanding peptide assembly and structure in membranes is vital.

Purpose of the Study:

  • To review studies on synthetic peptides from ion channels.
  • To analyze secondary structures and assembly of these peptides.
  • To compare findings with existing molecular models of ion channels.

Main Methods:

  • Synthesis of peptides corresponding to ion channel domains.
  • Incorporation of peptides into lipid bilayer membranes.
  • Structural and functional studies of reconstituted peptides.

Related Experiment Videos

Main Results:

  • Synthetic peptides can form ion channel activity in lipid bilayers.
  • Secondary structure and assembly modes are critical factors.
  • Data from ligand-gated, voltage-gated, and proton channels were analyzed.

Conclusions:

  • Synthetic transmembrane peptides offer insights into ion channel function.
  • Further research is needed on peptide assembly and structure-function relationships.
  • These studies contribute to understanding native ion channel mechanisms.