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Related Experiment Videos

Selenium deficiency and miscarriage: a possible link?

J W Barrington1, P Lindsay, D James

  • 1Department of Obstetrics and Gynaecology, Llandough Hospital, Penarth, United Kingdom.

British Journal of Obstetrics and Gynaecology
|February 1, 1996
PubMed
Summary

A significant decrease in serum selenium concentration was observed in women experiencing first trimester miscarriage. This finding suggests a potential link between low selenium levels and early pregnancy loss, warranting further investigation into selenium supplementation.

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Area of Science:

  • Reproductive Medicine
  • Nutritional Biochemistry

Background:

  • Serum selenium concentration naturally decreases during the first trimester of pregnancy.
  • Understanding factors influencing early pregnancy outcomes is crucial for maternal health.

Purpose of the Study:

  • To explore the association between serum selenium levels and first trimester miscarriage.
  • To determine if selenium deficiency is linked to nonrecurrent early pregnancy loss.

Main Methods:

  • Observational study conducted at a South Wales teaching hospital.
  • Measured serum selenium, albumin, and total protein in 40 women with first trimester miscarriage.
  • Compared results with 40 healthy nonpregnant volunteers and 40 pregnant women.

Main Results:

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  • Confirmed a normal reduction in serum selenium during early pregnancy.
  • Observed a statistically significant, further decrease in serum selenium in women who miscarried.
  • Indicates a potential role for selenium in maintaining early pregnancy.

Conclusions:

  • A pronounced decrease in serum selenium concentration is associated with first trimester miscarriage.
  • Further research is needed to evaluate the efficacy of selenium supplementation in preventing miscarriage.
  • This study highlights selenium as a potential biomarker and therapeutic target in early pregnancy complications.