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Antidepressant treatment influences cyclic AMP accumulation induced by excitatory amino acids in rat brain
The prolonged imipramine or electroconvulsive shock treatment induced a decrease in ibotenate stimulated increase in cyclic AMP accumulation as well as it inhibited the synergistic interaction between ibotenate and noradrenaline; the glutamate-mediated inhibition of forskolin-stimulated cyclic AMP accumulation was not modified. Our results indicate that certain subtypes of metabotropic glutamate receptor are differently modified by prolonged antidepressant treatment.
The prolonged imipramine or electroconvulsive shock treatment induced a decrease in ibotenate stimulated increase in cyclic AMP accumulation as well as it inhibited the synergistic interaction between ibotenate and noradrenaline; the glutamate-mediated inhibition of forskolin-stimulated cyclic AMP accumulation was not modified. Our results indicate that certain subtypes of metabotropic glutamate receptor are differently modified by prolonged antidepressant treatment.