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Acute leukemia with t(10;11)(p11-p15;q13-q23)

C Secco¹, P H Wiernik, J M Bennett

¹Department of Oncology, Montefiore and Albert Einstein Cancer Center, Bronx, New York 10467, USA.

Cancer Genetics and Cytogenetics

|January 1, 1996

Summary

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This study identifies a specific genetic abnormality, t(10;11), in acute leukemia patients. This chromosomal rearrangement may indicate a bipotential stem cell capable of developing into myeloid or T-lymphoid lineages.

Area of Science:

Hematology
Cytogenetics
Oncology

Background:

Acute leukemia presents diverse morphologic and immunophenotypic characteristics.
Chromosomal abnormalities are crucial in leukemia classification and prognosis.
The t(10;11) translocation is a rare cytogenetic finding in acute leukemia.

Observation:

Six patients with acute leukemia harboring the t(10;11)(p11-15;q13-q23) translocation were analyzed.
Morphological and cytochemical analysis revealed FAB-M5A and FAB-L1 subtypes.
Immunophenotyping indicated myeloid leukemia in five patients, with some expressing T-cell antigens or terminal transferase (TdT).

Findings:

One patient with FAB-L1 leukemia showed TdT+ and CD7+ acute myelomonocytic leukemia.
Two patients had differentiated acute myeloid leukemia (AML) with TdT expression.

Related Experiment Videos

A switch from monocytic to lymphoid morphology with a pre-T ALL immunophenotype was observed during relapse in one patient, without genotypic change.

Implications:

The t(10;11) translocation may arise from a bipotential myelomonocytic/T-lymphoid stem cell.
This finding contributes to understanding the stem cell origin of acute leukemia subtypes.
Further research into this specific translocation could refine diagnostic and therapeutic strategies for acute leukemia.