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Near-hexaploid Ph-positive acute myeloid leukemia with major-BCR/ABL transcript
H Iwama1, K Ohyashiki, J H Ohyashiki
1First Department of Internal Medicine, Tokyo Medical College, Japan.
Cancer Genetics and Cytogenetics
|January 1, 1996
Abstract:
We describe the first case of acute myeloid leukemia (AML) with a Philadelphia (Ph) translocation and a near-hexaploid range chromosome number, whose leukemic cells had the major-BCR/ABL transcript. The genesis of near-hexaploid leukemic cells might be due to endoreduplication of triploid leukemic cells with the Ph, since the relapsed leukemic cells had triploid range chromosomes with double Ph chromosomes.